Reactis is used by companies around the world in the automotive, aerospace/defense, heavy equipment, medical, and energy industries as well as in academia.
Some of the organizations that have purchased Reactis are:
| Advics | AESC Japan | Airbus |
| Aisin | Aptiv Components India Pvt. Ltd. | AVL |
| Azapa | Autoliv | BAE Systems |
| Bendix | BorgWarner | Bosch |
| Calsonic Kansei | Carmeq | Chimei Motor |
| China Institute of Aeronautical Radio Electronics | China Motor TW | Chrysler |
| Chung Shan Institute of Science and Technology | CK Electric Machinery Development | Collins Aerospace |
| Continental Automotive | DaeSung Electric | Daihatsu Motor |
| Daimler | Daimler Truck Innovation Center India | DIAS Automotive Electronic Systems China |
| Delphi Corporation | Delphi Diesel Systems | Delphi Propulsion Systems |
| Delphi Technical Center India | Delta Taiwan | Denso |
| DENSO TECHNO Co.,Ltd | Dongfeng Commercial Vehicle China | Dongfeng Motor Co., Ltd |
| Dongfeng Nissan Passenger Vehicle | Eaton | Fiat Chrysler Automobiles |
| Ford | Fraunhofer Center for Experimental Software Engineering | Fuji Heavy Industries |
| Fujitsu BSC Japan | Fujitsu Computer Technologies | GE Global Research |
| GE Transportation | General Motors | Gwangju Institute of Green-car Advancement |
| Hanhwa | Hitachi | Hitachi Astemo |
| Hitachi Automotive Systems, Ltd. | Hitachi Solutions Technology | Hitachi ULSI Systems Japan |
| Honda | Honda Elesys | Honeywell |
| Hyundai Autron | Hyundai Wia Korea | Imasen Electric Industrial |
| Isuzu | Jatco | John Deere |
| Karma | Keihin Corporation | Keihin Electronics Technology |
| Keihin R&D China | KPIT | Mando |
| Magneti Marelli India Pvt. Ltd. | Marelli | Mazda |
| McMaster University | Mercedes-Benz Research and Development | Mitsubishi |
| Mitsubishi Electric Control Software | Mitsubishi Electric Micro-Computer Application Software | Mitsubishi Motors |
| Mobis India | Nabtesco | Navistar |
| NASA Ames Research Center | Nexteer | Nissan |
| Nissan Techno Vietnam | Opel Automobile GmbH | Panasonic Advanced Technology Development |
| Panasonic Japan | Persol Excel HR Parters | Phinia Delphi |
| Pi Innovo | Quest Global Engineering | Renault |
| Renault Nissan India | Rockwell Collins | SAIC Motor Corporation |
| SGS Taiwan | SKY Japan | Smiths Medical |
| SRM Technologies | Stellantis | Strattec |
| Suzuki Motor Corporation | Taiwan Institute of Nuclear Energy Research | Tata Consultancy Services |
| Tata Elxsi | Tata Motors | The Software Beret |
| Toyota Motor Corporation | Toyota Technical Development Corp | Toyota Tsusho Denso Electronics Thailand |
| Transtron | TRW | University of Minnesota |
| Veoneer | Veoneer US Safety Systems | Vitesco |
| Witte Automotive France | Yamaha Motor Corporation | ZF |